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[S1E2] Some Of The Things That Molecules Do

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[S1E2] Some Of The Things That Molecules Do

The episode covers several facets of the origin of life and evolution. Tyson describes both artificial selection via selective breeding, using the example of mankind's domestication of wolves into dogs, and natural selection that created species like polar bears. Tyson uses the Ship of the Imagination to show how DNA, genes, and mutation work, and how these led to the diversity of species as represented by the Tree of Life, including how complex organs such as the eye came about as a common element.Tyson describes extinction of species and the five great extinction events that wiped out numerous species on Earth, while some species, such as the tardigrade, were able to survive and continue life. Tyson speculates on the possibility of life on other planets, such as Saturn's moon, Titan, as well as how abiogenesis may have originated life on Earth. The episode concludes with an animation from the original Cosmos showing the evolution of life from a single cell to mankind today, with music from Vivaldi's Mandolin Concerto.

Artificial selection is one example, eyes another, of the well-documented and inescapable process of evolution--change in a population of species over time--by natural selection. These are some of the things that molecules do.

He's also a pioneer in discovering and solving dermatological issues related to inflammation. That huge discovery will be our main area of focus today. Even though Dr. Perricone is best known for his books and his product line, he's a scientist at heart. As you're about to hear, he practices like one, and he talks like one, too. Our interview is pretty dense with science, but I also think it's extremely helpful, as Dr. Perricone tells a far deeper and more research-based story about the anti-inflammation movement than most practitioners can. He's also working on something new that he thinks might change your life. Stick with me, nerds, don't go away.

I looked at that and said, "Hmm, that's pretty interesting," and I talked to the professor and I said, "Is it possible that the inflammatory process is somehow mediating or driving the results here?" It was kind of a cursory answer like, "No, no, that's just the immune system reacting." I thought, "Gee, I didn't think the immune system reacted because the tumor tend to bypass." I kept that in mind, and we started looking at tissue samples of arteries and atherosclerosis, and there's inflammatory infiltrate in the muscular part of the artery.

[Dr. Nicholas Perricone] But, it's interesting, looking at tissue of adults, older adults. Without any pathology there, without any lesion, there was this generalized inflammation. I said, "That's crazy, that's just aged skin, and it's inflamed? What's going on here?" Of course, young skin has no inflammation unless there's some pathology present. That's where I really started saying, "Okay, I think I understand what's going on." But what was interesting, I said, "Okay, I understand skin to some extent because it protects us, it's the interface. But, what about the internal organs? What's going on in the arteries, what's going on in the heart, what's going on in the liver?" Being a nutritionist, I said, "Well, what do we do four or five times a day? We eat."

[Dr. Nicholas Perricone] It's a protein that's probably produced by the liver, and it's produced in response to general inflammation. And so, it's measurable by a simple lab test. You want to check C-reactive protein, because C-reactive protein is extremely predictive of things like cardiovascular disease. If you have high C-reactive protein... Or it's also indicative of a focus of inflammation. For example, if you have prostatitis or something. C-reactive protein, of course, it's high if you have autoimmune disease. And so, a way to follow and also search for certain diseases.

But, anyway, it's interesting that once I started looking at it and things were refined, there was a direct relationship bet


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